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4-1BBL expressed by eukaryotic cells activates immune cells and suppresses the progression of murine

Hui QIU, Hui ZHANG, Zuohua FENG

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 20-25 doi: 10.1007/s11684-009-0006-9

Abstract: The interaction by co-stimulatory molecules 4-1BB and 4-1BB ligand (4-1BBL) plays an important role inThe function of 4-1BB/4-1BBL expressed by the immune cells has been the focus for many tumor immunotherapyIn this study, 4-1BBL was expressed in non-immune cells and non-tumor cells, and the role of 4-1BBL inThe plasmid p4-1BBL containing the full length of mouse 4-1BBL cDNA sequence was constructed, and theThe study demonstrated that the molecule 4-1BBL expressed by BHK cells could enhance the proliferation

Keywords： 4-1BB ligand     tumor immunotherapy     tumor microenvironment    

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Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms

Frontiers of Medicine   Pages 805-822 doi: 10.1007/s11684-023-1025-7

Abstract: To date, immune checkpoint inhibitors (ICIs) of CTLA-4 and PD-1/PD-L1 represent the main class of immunotherapyBlockade of CTLA-4 and PD-1/PD-L1 has shown remarkable efficacy in several specific types of cancers,the generalized mechanism of targeting cancer metabolism at three crucial immune checkpoints (CTLA-4,PD-1, and PD-L1) to influence ICB therapy and propose potential combined immunotherapeutic strategies

Keywords： CTLA-4     PD-1     PD-L1     immune checkpoint blockade (ICB)     metabolic reprogramming     combined tumor therapeutic    

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Synthesis, insecticidal activities and DFT study of pyrimidin-4-amine derivatives containing the 1,2,4

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 7,   Pages 1090-1100 doi: 10.1007/s11705-021-2091-5

Abstract: Twenty six novel pyrimidin-4-amine derivatives containing the 1,2,4-oxadiazole motif were synthesizedTheir chemical structures were confirmed by 1H nuclear magnetic resonance (NMR), 13

Keywords： synthesis     pyrimidin-4-amine derivatives     1     2     4-oxadiazole     insecticidal activity     structure-activity    

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Wideband circular-polarized transmitarray for generating a high-purity vortex beam Correspondence

Liangjie QIU, Xiuping LI, Zihang QI, Wenyu ZHAO, Yuhan HUANG,xpli@bupt.edu.cn

Frontiers of Information Technology & Electronic Engineering 2023, Volume 24, Issue 6,   Pages 927-934 doi: 10.1631/FITEE.2200539

Abstract: structure and double-resonance characteristics ensure the stable phase shift of the element within the 1-Owing to the honeycomb arrangement of elements, the mode purity of l​​=​​−1 is >0.93 in a wide band from

Keywords： 轨道角动量；涡旋波束；透射阵；宽带；高纯度    

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Microwave-assisted synthesis and antimicrobial activities of 2-aryl-3-(naphthalene-1 or 2-yl)-1,3-thiazolidin-4-ones

Hua CHEN, Yanan LI, Jie BAI, Lian ZHAO, Xiangguo YUAN, Xiaoliu LI, Keqiang CAO

Frontiers of Chemical Science and Engineering 2009, Volume 3, Issue 2,   Pages 186-191 doi: 10.1007/s11705-009-0004-0

Abstract: 2-aryl-3-(naphthalene-1 or 2-yl)-1,3-thiazolidin-4-ones and were synthesized in 41%-67% yield by

Keywords： microwave-assisted synthesis     naphthyl     thiazolidin-4-one     antimicrobial    

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Surface modification by ligand growth strategy for dense copper bismuth film as photocathode to enhance

Frontiers in Energy doi: 10.1007/s11708-023-0893-5

Abstract: Herein, a straightforward sol-gel method with the ligand-induced growth strategy was employed to obtainvarious characterizations, it was found that the nucleation and surface growth of CuBi2O4 layer induced by 2-methoxyethanol ligand (2-CuBi2O4) demonstrated a decent, under simulated sunlight irradiation (AM1.5G, 100 mW/cm2), the 2-CuBi2O4ligand growth strategy will shed light on the future design of advanced

Keywords： copper bismuthate     photocathode     ligand growth strategy     dense film     PEC    

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China in the eyes of news media: a case study under COVID-19 epidemic Research Article

Hong Huang, Zhexue Chen, Xuanhua Shi, Chenxu Wang, Zepeng He, Hai Jin, Mingxin Zhang, Zongya Li,honghuang@hust.edu.cn,chenzhexue@hust.edu.cn,xhshi@hust.edu.cn,wangchenxu@hust.edu.cn,hezepeng@hust.edu.cn,hjin@hust.edu.cn,mingxinzhang@hust.edu.cn,lzy901014@sina.com

Frontiers of Information Technology & Electronic Engineering 2021, Volume 22, Issue 11,   Pages 1443-1457 doi: 10.1631/FITEE.2000689

Abstract: We aim to answer three questions: (1) What has the international media focused on during the period?

Keywords： 国家形象；新冠肺炎；主题挖掘；实体；新闻立场；情感    

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Synaptic devices based on semiconductor nanocrystals Review

Mingxuan BU, Yue WANG, Lei YIN, Zhouyu TONG, Yiqiang ZHANG, Deren YANG, Xiaodong PI

Frontiers of Information Technology & Electronic Engineering 2022, Volume 23, Issue 11,   Pages 1579-1601 doi: 10.1631/FITEE.2100551

Abstract:

To meet a growing demand for information processing, brain-inspired neuromorphic devices have been intensively studied in recent years. As an important type of neuromorphic device, have attracted strong attention. Among all the kinds of materials explored for the fabrication of , s (NCs) have become one of the preferred choices due to their excellent electronic and optical properties. In this review, we first introduce the research background of based on semiconductor NCs and briefly present the basic properties of semiconductor NCs. Recent developments in the field of based on semiconductor NCs are then discussed according to the materials employed in the active layers of the devices. Finally, we discuss existing problems and challenges of based on semiconductor NCs.

Keywords： Semiconductor nanocrystal     Synaptic devices     Neuromorphic computing    

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Highly selective detection of copper(II) by a “ligand-free” conjugated copolymer in nucleophilic solvents

Weixing Deng, Pengfei Sun, Quli Fan, Lei Zhang, Tsuyoshi Minami

Frontiers of Chemical Science and Engineering 2020, Volume 14, Issue 1,   Pages 105-111 doi: 10.1007/s11705-019-1791-6

Abstract: -cyclohexyl carbamate-attached fluorene- -phenylene copolymer (PFPNCC) and the use of PFPNCC as a “ligand-freePFPNCC in nucleophilic solvents such as DMF and DMSO, but not in low nucleophilic solvents such as 1,4strategy for highly selective conjugated polymer-based chemosensors for various target analytes, albeit “ligand-free

Keywords： ligand-free     fluorescent chemosensor     copper     photo-induced electron transfer    

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Passive mode-locked Er-doped fiber laser pulse generation based on titanium disulfide saturable absorber Research Articles

Xinxin Shang, Linguang Guo, Huanian Zhang, Dengwang Li, Qingyang Yue,huanian_zhang@163.com,qingyangyue@sdnu.edu.cn

Frontiers of Information Technology & Electronic Engineering 2021, Volume 22, Issue 5,   Pages 615-766 doi: 10.1631/FITEE.2000341

Abstract: In this study, (TiS) polyvinyl alcohol (PVA) film-type (SA) is synthesized with a modulation depth of 5.08% and a saturable intensity of 10.62 MW/cm by liquid-phase exfoliation and spin-coating methods. Since TiS-based SA has a strong nonlinear saturable absorption property, two types of optical soliton were observed in a mode-locked Er-doped . When the pump power was raised to 67.3 mW, a conventional mode-locked pulse train with a repetition rate of 1.716 MHz and a pulse width of 6.57 ps was generated, and the output spectrum centered at 1556.98 nm and 0.466 nm spectral width with obvious Kelly sidebands was obtained. Another type of mode-locked pulse train with the maximum output power of 3.92 mW and pulse energy of 2.28 nJ at the pump power of 517.2 mW was achieved when the polarization controllers were adjusted. Since TiS-based SA has excellent nonlinear saturable absorption characteristics, broad applications in ultrafast photonic are expected.

Keywords： 光纤激光器；被动锁模；可饱和吸收体；二硫化钛    

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Synthesis of vinylferrocene and the ligand-exchange reaction between its copolymer and carbon nanotubes

Ran SHI,Hai WANG,Ping TANG,Yuezhen BIN

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 2,   Pages 171-178 doi: 10.1007/s11705-014-1428-8

Abstract: nanotubes (CNTs), poly(vinylferrocene- -styrene) (poly(Vf- -St)), was grafted onto the surface of CNTs by a ligand-exchangeelectrical conductivity of composites prepared from the polymer-grafted CNTs and copolymer (acrylonitrile, 1,3

Keywords： vinylferrocene     poly (Vf-co-St)     CNTs     dispersibility    

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Development of space-based diffractive telescopes Review Article

Wei Zhao, Xin Wang, Hua Liu, Zi-feng Lu, Zhen-wu Lu,wangxin971241@163.com,liuhua_rain@aliyun.com

Frontiers of Information Technology & Electronic Engineering 2020, Volume 21, Issue 6,   Pages 809-962 doi: 10.1631/FITEE.1900529

Abstract: formed by fabricating microstructures on the substrates have two important characteristics, ultra-light mass (surface mass density < 0.1 kg/m2) and loose surface shape tolerances (surface accuracy requirements are on the order of magnitude of centimeter). Large-aperture telescopes using a membrane diffractive optical element as the primary lens have , light weight, and low cost at launch. In this paper, the research and development on space-based s are classified and summarized. First, the imaging theory and the configuration of diffractive-optics telescopes are discussed. Then, the developments in s are introduced. Finally, the development prospects for this technology used as a high-resolution space reconnaissance system in the future are summarized, and the critical and relevant work that China should carry out is put forward.

Keywords： 薄膜衍射光学元件；衍射望远系统；超大口径    

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Transcription Factors HNF1A, HNF4A, and FOXA2 Regulate Hepatic Cell Protein N-Glycosylation Article

Vedrana Vičić Bočkor,Nika Foglar,Goran Josipović,Marija Klasić,Ana Vujić,Branimir Plavša,Toma Keser,Samira Smajlović,Aleksandar Vojta,Vlatka Zoldoš

Engineering 2024, Volume 32, Issue 1,   Pages 58-69 doi: 10.1016/j.eng.2023.09.019

Abstract:

Hepatocyte nuclear factor 1 alpha (HNF1A), hepatocyte nuclear factor 4 alpha (HNF4A), and forkheadOur in silico analysis of HNF1A, HNF4A, and FOXA2 binding to the 10 candidate glyco-genes studiedshort palindromic repeats/dead Cas9 (CRISPR/dCas9) molecular tool for the downregulation of the HNF1A, HNF4A, and FOXA2 genes in HepG2 cells—a human liver cancer cell line.We also propose a model showing feedback loops with the mutual activation of HNF1A–FOXA2 and HNF4A

Keywords： interspaced short palindromic repeats/dead Cas9 (CRISPR/dCas9)     Epigenetics     Hepatocyte nuclear factor 1alpha (HNF1A)     Hepatocyte nuclear factor 4 alpha (HNF4A)     Forkhead box protein A2 (FOXA2)     N-glycosylation    

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Design, synthesis, and antiviral properties of 2-aryl-1H-benzimidazole-4-carboxamide derivatives

Xianjin LUO, Zhonglü ZHANG, Yutian YANG, Fei XUE, Naiyun XIU, Yuanbin SHE

Frontiers of Chemical Science and Engineering 2009, Volume 3, Issue 3,   Pages 305-309 doi: 10.1007/s11705-009-0021-z

Abstract: A series of new benzimidazole derivatives were designed and synthesized. Their chemical structures were testified by H NMR, infrared spectroscopy (IR), mass spectrography (MS), and elemental analysis. Their potent antiviral properties indicated the prospect of new drugs. Compound , , , , , , and were identified as novel antivirus with much better selective activity and inhibitory activity than the comparable ribavirin against Coxsackie virus B in VERO cells.

Keywords： benzimidazole     coxsackie virus B3     antiviral properties    

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Effect of ligand chain length on hydrophobic charge induction chromatography revealed by molecular dynamics

Lin ZHANG, Yan SUN

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 4,   Pages 456-463 doi: 10.1007/s11705-013-1357-y

Abstract: The effect of the ligand chain length on protein behavior in HCIC was studied.with different chain lengths, including one with shorter ligands (CL2) and one with longer ligands (CL4)The adsorption, desorption, and conformational transition of the proteins with CL2 and CL4 were examinedThe ligand chain length has a significant effect on both the probability and the irreversibility of theThe simulation results elucidated the effect of the ligand chain length, which is beneficial for the

Keywords： adsorption     desorption     irreversibility     protein conformational transition     molecular dynamics simulation    

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Title Author Date Type Operation

4-1BBL expressed by eukaryotic cells activates immune cells and suppresses the progression of murine

Hui QIU, Hui ZHANG, Zuohua FENG

Journal Article

Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms

Journal Article

Synthesis, insecticidal activities and DFT study of pyrimidin-4-amine derivatives containing the 1,2,4

Journal Article

Wideband circular-polarized transmitarray for generating a high-purity vortex beam

Liangjie QIU, Xiuping LI, Zihang QI, Wenyu ZHAO, Yuhan HUANG,xpli@bupt.edu.cn

Journal Article

Microwave-assisted synthesis and antimicrobial activities of 2-aryl-3-(naphthalene-1 or 2-yl)-1,3-thiazolidin-4-ones

Hua CHEN, Yanan LI, Jie BAI, Lian ZHAO, Xiangguo YUAN, Xiaoliu LI, Keqiang CAO

Journal Article

Surface modification by ligand growth strategy for dense copper bismuth film as photocathode to enhance

Journal Article

China in the eyes of news media: a case study under COVID-19 epidemic

Hong Huang, Zhexue Chen, Xuanhua Shi, Chenxu Wang, Zepeng He, Hai Jin, Mingxin Zhang, Zongya Li,honghuang@hust.edu.cn,chenzhexue@hust.edu.cn,xhshi@hust.edu.cn,wangchenxu@hust.edu.cn,hezepeng@hust.edu.cn,hjin@hust.edu.cn,mingxinzhang@hust.edu.cn,lzy901014@sina.com

Journal Article

Synaptic devices based on semiconductor nanocrystals

Mingxuan BU, Yue WANG, Lei YIN, Zhouyu TONG, Yiqiang ZHANG, Deren YANG, Xiaodong PI

Journal Article

Highly selective detection of copper(II) by a “ligand-free” conjugated copolymer in nucleophilic solvents

Weixing Deng, Pengfei Sun, Quli Fan, Lei Zhang, Tsuyoshi Minami

Journal Article

Passive mode-locked Er-doped fiber laser pulse generation based on titanium disulfide saturable absorber

Xinxin Shang, Linguang Guo, Huanian Zhang, Dengwang Li, Qingyang Yue,huanian_zhang@163.com,qingyangyue@sdnu.edu.cn

Journal Article

Synthesis of vinylferrocene and the ligand-exchange reaction between its copolymer and carbon nanotubes

Ran SHI,Hai WANG,Ping TANG,Yuezhen BIN

Journal Article

Development of space-based diffractive telescopes

Wei Zhao, Xin Wang, Hua Liu, Zi-feng Lu, Zhen-wu Lu,wangxin971241@163.com,liuhua_rain@aliyun.com

Journal Article

Transcription Factors HNF1A, HNF4A, and FOXA2 Regulate Hepatic Cell Protein N-Glycosylation

Vedrana Vičić Bočkor,Nika Foglar,Goran Josipović,Marija Klasić,Ana Vujić,Branimir Plavša,Toma Keser,Samira Smajlović,Aleksandar Vojta,Vlatka Zoldoš

Journal Article

Design, synthesis, and antiviral properties of 2-aryl-1H-benzimidazole-4-carboxamide derivatives

Xianjin LUO, Zhonglü ZHANG, Yutian YANG, Fei XUE, Naiyun XIU, Yuanbin SHE

Journal Article

Effect of ligand chain length on hydrophobic charge induction chromatography revealed by molecular dynamics

Lin ZHANG, Yan SUN

Journal Article